{"id":66563,"date":"2026-01-15T13:50:39","date_gmt":"2026-01-15T12:50:39","guid":{"rendered":"https:\/\/www.hiperbaric.com\/?p=66563"},"modified":"2026-02-26T12:19:47","modified_gmt":"2026-02-26T11:19:47","slug":"high-pressure-processing-hpp-for-milk-preservation-safety-shelf-life-and-raw%e2%80%91like-quality","status":"publish","type":"post","link":"https:\/\/www.hiperbaric.com\/en\/high-pressure-processing-hpp-for-milk-preservation-safety-shelf-life-and-raw%e2%80%91like-quality\/","title":{"rendered":"High-Pressure Processing (HPP) for Milk Preservation: Safety, Shelf Life, and Raw\u2011Like Quality"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-66586\" src=\"https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/HPP-Food-Science-Newsletter-Milk-300x169.jpg\" alt=\"\" width=\"600\" height=\"338\" srcset=\"https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/HPP-Food-Science-Newsletter-Milk-300x169.jpg 300w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/HPP-Food-Science-Newsletter-Milk-1024x576.jpg 1024w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/HPP-Food-Science-Newsletter-Milk-768x432.jpg 768w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/HPP-Food-Science-Newsletter-Milk-1536x864.jpg 1536w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/HPP-Food-Science-Newsletter-Milk-1260x709.jpg 1260w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/HPP-Food-Science-Newsletter-Milk-630x354.jpg 630w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/HPP-Food-Science-Newsletter-Milk-420x236.jpg 420w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/HPP-Food-Science-Newsletter-Milk-840x473.jpg 840w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/HPP-Food-Science-Newsletter-Milk-315x177.jpg 315w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/HPP-Food-Science-Newsletter-Milk.jpg 1920w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>Milk is one of the most <strong>nutrient-dense everyday foods<\/strong>, providing high-quality proteins, minerals, and vitamins. Yet, when consumed raw, it can also carry <strong>biological hazards<\/strong>, with outbreaks historically linked to pathogens such as <em>Listeria monocytogenes<\/em>, <em>Salmonella<\/em> spp., <em>Campylobacter<\/em> spp., and Shiga toxin-producing <em>Escherichia coli<\/em> (STEC).<\/p>\n<p>For over a century, the dairy industry has relied on <strong>thermal pasteurization<\/strong> to ensure safety, but heat can also drive quality trade-offs and contribute to sensory alterations.\u00a0 This is why emerging nonthermal technologies are gaining momentum. Among them, <strong>High-Pressure Processing (HPP)<\/strong> stands out as a promising route to reduce microbial risk while preserving a more raw-like sensory profile and much of milk\u2019s nutritional value. Turning that promise into routine commercial practice, however, still depends on meeting regulatory expectations for validation and verification.<\/p>\n<h2>Milk and Nutritional Properties<\/h2>\n<p>Recent data in raw cow milk suggest that <strong>nutritional value can be largely preserved<\/strong> immediately after HPP, with vitamins and minerals remaining comparable to untreated milk under intense conditions (6000 bar\/87 kpsi, 10 min) <strong>(Figure 1)<\/strong>. Importantly, vitamin stability is still governed by storage: some vitamins (A, B3, B5, B6, C) decline gradually over refrigerated storage after HPP, but untreated raw milk can degrade even faster.<\/p>\n<figure id=\"attachment_66567\" aria-describedby=\"caption-attachment-66567\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-66567\" src=\"https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-1-300x195.jpg\" alt=\"\" width=\"600\" height=\"389\" srcset=\"https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-1-300x195.jpg 300w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-1-1024x664.jpg 1024w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-1-768x498.jpg 768w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-1-1536x996.jpg 1536w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-1-2048x1329.jpg 2048w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-1-1260x817.jpg 1260w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-1-630x409.jpg 630w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-1-420x272.jpg 420w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-1-840x545.jpg 840w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-1-315x204.jpg 315w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-66567\" class=\"wp-caption-text\"><strong>Figure 1<\/strong>. Vitamin and mineral concentrations in raw vs HPP milk <a href=\"https:\/\/www.mdpi.com\/2304-8158\/12\/3\/592\">(Lim et al. 2023)<\/a><\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<h2>The Potential of HPP to Inactivate Pathogens and Ensure Safety<\/h2>\n<p>Raw milk safety remains a public-health concern. A US analysis (2013\u20132018) reported around <strong>75 outbreaks<\/strong> linked to raw milk, with most occurring where sales were permitted, especially where retail sale was allowed <a href=\"https:\/\/www.cambridge.org\/core\/journals\/epidemiology-and-infection\/article\/foodborne-%5b%E2%80%A6%5dlaws-united-states-19982018\/4822109E69DDAB37E92CAAB41AB1CC0F\">(Koski et al. 2022)<\/a>.<\/p>\n<p>Multiple challenge studies indicate that HPP at 6000 bar (87 kpsi) can deliver several log reductions of key vegetative pathogens, including <em>L. monocytogenes<\/em>, <em>Salmonella<\/em> spp., and <em>E. coli<\/em> <strong>(Figure 2)<\/strong>. However, a recurring limitation in published research is that post\u2011process pathogen evolution during storage is often not monitored, and some studies use UHT milk for inoculation, which may not fully represent raw milk behavior.<\/p>\n<figure id=\"attachment_66570\" aria-describedby=\"caption-attachment-66570\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-66570\" src=\"https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-2-300x195.jpg\" alt=\"\" width=\"600\" height=\"389\" srcset=\"https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-2-300x195.jpg 300w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-2-1024x664.jpg 1024w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-2-768x498.jpg 768w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-2-1536x996.jpg 1536w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-2-2048x1329.jpg 2048w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-2-1260x817.jpg 1260w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-2-630x409.jpg 630w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-2-420x272.jpg 420w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-2-840x545.jpg 840w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-2-315x204.jpg 315w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-66570\" class=\"wp-caption-text\"><strong>Figure 2.<\/strong> Pathogen inactivation in raw milk <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1466856418310555\">(Stratakos et al. 2019)<\/a><\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>HPP may also help address emerging hazards such as avian influenza. While its effectiveness against H5N1 in milk remains uncertain, results for other subtypes (e.g., H7N7) in other matrices suggest that sufficiently intense pressure treatments can markedly reduce viral titers <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0362028X22060720\">(Isbarn et al. 2007).<\/a><\/p>\n<h2>The Potential of HPP to Extend Shelf Life by Controlling Spoilage Microorganisms<\/h2>\n<p>Beyond safety, HPP can meaningfully reduce spoilage microbiota in milk. For example, 6000 bar (87 kpsi) for 3 min achieved a 4 log reduction of total viable counts and &gt;2.7 log reduction of <em>Enterobacteriaceae<\/em>, followed by delayed growth under refrigeration compared with untreated milk, which extended shelf life up to 21 days under refrigeration <strong>(Figure 3).<\/strong><\/p>\n<figure id=\"attachment_66573\" aria-describedby=\"caption-attachment-66573\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-66573\" src=\"https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-3-300x195.jpg\" alt=\"\" width=\"600\" height=\"389\" srcset=\"https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-3-300x195.jpg 300w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-3-1024x664.jpg 1024w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-3-768x498.jpg 768w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-3-1536x996.jpg 1536w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-3-2048x1329.jpg 2048w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-3-1260x817.jpg 1260w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-3-630x409.jpg 630w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-3-420x272.jpg 420w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-3-840x545.jpg 840w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-3-315x204.jpg 315w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-66573\" class=\"wp-caption-text\"><strong>Figure 3<\/strong>. Evolution of total viable counts in raw milk after HPP <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1466856418310555\">(Stratakos et al. 2019)<\/a><\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>Across studies, shelf life outcomes vary with conditions and initial microbiota, but reports include:<\/p>\n<ul>\n<li>Up to 60 days at 6\u202f\u00b0C (43 \u00b0F) after 6000 bar (87 kpsi) for 10 min, with an initial total viable count (TVC) in raw milk of 5 log cfu\/mL <a href=\"https:\/\/www.mdpi.com\/2304-8158\/12\/3\/592\">(Huey Lim et al. 2023)<\/a>.<\/li>\n<li>More than 30 days at 6\u202f\u00b0C (43 \u00b0F) after 6000 bar (87 kpsi) for 15 min, with an initial TCV of 4.5 log cfu\/mL <a href=\"https:\/\/www.mdpi.com\/2304-8158\/11\/18\/2837\">(Yu et al. 2022)<\/a>.<\/li>\n<li>More than 22 days at 8 \u00b0C (46 \u00b0F) after 6000 bar (87 kpsi) for 3 min, with an initial TVC of 5 log cfu\/mL <a href=\"https:\/\/www.mdpi.com\/2227-9717\/8\/6\/697\">(Fern Tan et al. 2020)<\/a>.<\/li>\n<\/ul>\n<h2>The Potential of HPP to Retain Sensory Quality<\/h2>\n<p>HPP is often presented as a way to deliver \u201craw-like\u201d milk because it avoids many of the flavor changes associated with heat treatment. Sensory studies report only minor differences between untreated and pressure-treated milk across several attributes, and panelists generally preferred HPP-treated milk to pasteurized milk <strong>(Figure 4)<\/strong>.<\/p>\n<figure id=\"attachment_66576\" aria-describedby=\"caption-attachment-66576\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-66576\" src=\"https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-4-300x195.jpg\" alt=\"\" width=\"600\" height=\"389\" srcset=\"https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-4-300x195.jpg 300w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-4-1024x664.jpg 1024w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-4-768x498.jpg 768w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-4-1536x996.jpg 1536w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-4-2048x1329.jpg 2048w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-4-1260x817.jpg 1260w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-4-630x409.jpg 630w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-4-420x272.jpg 420w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-4-840x545.jpg 840w, https:\/\/www.hiperbaric.com\/wp-content\/uploads\/2026\/01\/Figure-4-315x204.jpg 315w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-66576\" class=\"wp-caption-text\"><strong>Figure 4.<\/strong> Sensory scores comparing untreated, high-pressure processed, and pasteurized milk <a href=\"https:\/\/lbtufb.lbtu.lv\/conference\/foodbalt\/2017\/Liepa_Zagorska_Galoburda_Straumite_Kruma_Sabovics_FoodBalt2017.pdf\">(Liepa et al. 2017)<\/a><\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>That said, appearance can shift in raw, unhomogenized milk: HPP may increase the yellow color component <em>b*<\/em>, likely linked to micellar changes that increase light interaction with the lipid fraction. Notably, color differences (DE) can be smaller than heat treatment under some conditions (e.g., 6000 bar \/ 87 kpsi for 3 min vs 72\u202f\u00b0C \/ 161 \u00b0F for 5 min) <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1466856418310555\">(Stratakos et al. 2019)<\/a>.<\/p>\n<h2>Regulatory Situation<\/h2>\n<p>Several agencies and expert groups acknowledge the potential of HPP but also highlight gaps. New Zealand\u2019s review concluded there is <strong>no \u201csafe harbor\u201d<\/strong> (no default parameters usable without further validation), and pointed to challenges with <strong>verification indicators<\/strong> (e.g., alkaline phosphatase is pressure\u2011resistant and not a suitable performance indicator for HPP).<\/p>\n<p>European risk-based assessments have proposed time\/pressure combinations to meet performance criteria for multiple pathogens, while also warning about challenges with <strong>process verification<\/strong>.<\/p>\n<p>In the United States, the situation is particularly stringent because pasteurization equivalence traditionally links to inactivation of <strong><em>Coxiella burnetii<\/em><\/strong> (historically used as the benchmark organism). Alternative processes must demonstrate equivalence and consider revalidation when hazards and\/or processes change. This raises practical challenges regarding reference organism selection and robust protocols for process validation.<\/p>\n<h2>Take-home Message<\/h2>\n<p>HPP can enable <strong>safe, extended<\/strong><strong>\u2011<\/strong><strong>shelf<\/strong><strong>\u2011<\/strong><strong>life, <\/strong><strong>\u201c<\/strong><strong>raw<\/strong><strong>\u2011<\/strong><strong>like<\/strong><strong>\u201d<\/strong><strong> milk<\/strong>, but the industry needs better-defined validation playbooks. Evidence shows strong pathogen and spoilage reductions and promising sensory retention, yet gaps remain around benchmark targets, post\u2011process behavior during storage, and universally accepted verification indicators.<\/p>\n<p>One possible approach is to use HPP as a <strong>shelf<\/strong><strong>\u2011life\u2011extension step<\/strong> for milk that has <strong>already undergone a validated lethal treatment<\/strong> for pathogen control, such as Long-Temperature Long-Time (LTLT), which is claimed to minimally affect milk quality compared with other pasteurization treatments at higher temperatures.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Milk is one of the most nutrient-dense everyday foods, providing high-quality proteins, minerals, and vitamins. Yet, when consumed raw, it can also carry biological hazards, with outbreaks historically linked to pathogens such as Listeria monocytogenes, Salmonella spp., Campylobacter spp., and Shiga toxin-producing Escherichia coli (STEC). For over a century, the dairy industry has relied&#8230;<\/p>\n","protected":false},"author":17,"featured_media":67073,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_wp_rev_ctl_limit":""},"categories":[266,253],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>High-Pressure Processing (HPP) for Milk Preservation: Safety, Shelf Life, and Raw\u2011Like Quality - Hiperbaric<\/title>\n<meta name=\"description\" content=\"Emerging nonthermal technologies are gaining momentum. 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