{"id":30237,"date":"2021-06-01T11:11:52","date_gmt":"2021-06-01T09:11:52","guid":{"rendered":"https:\/\/www.hiperbaric.com\/cosmetica-y-farmaceutica-desarrollo-de-productos-sin-aditivos-seguros-y-eficaces-con-hpp\/"},"modified":"2021-06-01T12:41:44","modified_gmt":"2021-06-01T10:41:44","slug":"cosmetic-and-pharmaceutical-industry-development-with-hpp-of-safe-and-effective-products-without-additives","status":"publish","type":"post","link":"https:\/\/www.hiperbaric.com\/en\/cosmetic-and-pharmaceutical-industry-development-with-hpp-of-safe-and-effective-products-without-additives\/","title":{"rendered":"Cosmetic and pharmaceutical industry: development with hpp of safe and effective products without additives"},"content":{"rendered":"

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In recent years, an increasing number of scientific disciplines have shown interest in the potential of High Hydrostatic Pressure Processing (HPP). Such is the case of the Pharmaceutical and Cosmetic Industries, which have recently begun to leverage and develop the many possibilities offered by this technology. In this post, we present you the main commercial applications of HPP for pharmaceuticals and cosmetics that, in addition, you\u2019ll be able to discover in detail during the session \u201cInnovating Pharma & Cosmetic Products using HPP\u201d, offered during the HPP Innovation Week.<\/strong><\/p>\n

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Inactivation of biological agents (bacteria, moulds, yeasts and virus)<\/h2>\n

The main commercial application of HPP in this field is the inactivation of biological agents <\/strong>(bacteria, moulds, yeasts and virus), i.e. in the so-called \u201cpascalization\u201d of thermo-, chemo- or radiosensitive materials.<\/p>\n

Going into more detail, this application can be classified into three subcategories according to the main objective sought:<\/p>\n

Development of organic and additive-free cosmetics<\/h3>\n

Thanks to the inactivation of pathogens provided by HPP, it is possible to develop microbiologically safe products with a longer shelf life, preserving the functionality and activity of thermolabile molecules. This is the example of Lycolab<\/a>, a biotechnology company with participation in the HPP Innovation Week, where you\u2019ll be able to learn in detail their experience with the use of HPP in obtaining biocollagen. Briefly, thanks to a combined process of lyophilization and high pressure (HPP), they have managed to develop a microbiologically safe biocollagen product, without the use of preservatives or stabilizers, which also maintains all the functionality of this beneficial substance.<\/p>\n

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Figure 1. Lycolab process combining HPP and lyophilization to obtain biocollagen<\/figcaption><\/figure>\n

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So, as ECOCERT has already certified, it is a completely natural raw material<\/strong> that respects both the animal that secretes it (common garden snail), and the environment.<\/p>\n

Development of even safer pharmaceutical products<\/h3>\n

In this regard, another option is to further increase the safety of already sterile pharmaceutical products, thanks to this additional microbiological inactivation<\/strong> step with HPP after packaging.<\/strong> This is the case of Bioluz<\/a>, a pharmaceutical laboratory that will also explain in this session their experience with the use of HPP technology for this purpose.<\/p>\n

Development of new vaccines<\/h3>\n

Finally, another potential application following the microbiological inactivation provided by HPP, includes the development of new vaccines with pressure inactivated pathogens, but retaining, or even improving their immunogenicity. From the University of Aveiro, Dr. Saraiva will explain the subject in more detail during this session of the HPP Innovation Week.<\/p>\n

Production of modified proteins of medical or pharmaceutical interest<\/h2>\n

The next commercial application of HPP in Pharmacy and Cosmetics consists in the production of modified proteins<\/strong> of medical or pharmaceutical interest.<\/p>\n

The effect of HPP on proteins has been extensively studied: although pressure values > 400 MPa can denature proteins, milder pressure conditions (\u0334 200 MPa) often only affect the quaternary structure, leading to the dissociation of oligomeric proteins. In this sense, it must be pointed out the BaroFold High Pressure Refolding Technology. Specifically, it consists of subjecting protein aggregates to high pressure, which allows their dissociation and subsequent accurate refolding of the constituent proteins.<\/p>\n

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Figure 2. Pressure effects on protein aggregates. As shown here, a pressure increase can dissociate and unfold protein aggregates. Upon decompression, proteins refold into their stable native conformations.<\/figcaption><\/figure>\n

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This process includes benefits such as:<\/p>\n